Valuation: Silence Therapeutics plc

Market Cap 610M 826M 713M 670M 1.15B 78.99B 1.17B 7.86B 3.07B 39.56B 3.1B 3.03B 131B P/E 2026 *
-20.3x
P/E 2027 * -16.8x
Enterprise Value 477M 646M 558M 524M 896M 61.75B 911M 6.14B 2.4B 30.92B 2.42B 2.37B 103B EV / Sales 2026 *
1,468x
EV / Sales 2027 * 581x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: Silence Therapeutics plc

1 day-1.61%
1 week+15.02%
Current month+31.03%
1 month+25.87%
3 months+125.33%
6 months+208.88%
Current year+126.07%
1 week 13.36
Extreme 13.36
16.52
1 month 10.16
Extreme 10.16
17.58
Current year 4.19
Extreme 4.19
17.58
1 year 4.19
Extreme 4.19
17.58
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap.
6/7/26 Sell 865,112 0.6105%
2/1/26 Free

Chief Financial Officer

375,000 0.2646%
2/1/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-1.61%+15.02%+150.59%+111.46% 826M
+0.14%-2.80%+1.37%+19.06% 48.42B
+0.85%-0.70%+460.88%+581.30% 43.66B
-2.40%-0.23%+8.13%+80.67% 39.51B
-2.01%-0.85%+23.85%+9.97% 38.95B
-0.50%+0.85%+20.60%+58.18% 32.61B
+0.38%-3.23% - - 16.32B
-0.59%-2.06%+26.35%+126.36% 16.15B
-1.45%-0.89%+3.09%+26.68% 14.16B
-0.43%+4.70%+78.74%+38.66% 13.37B
Average -0.77%+1.19%+85.95%+116.93% 26.4B
Weighted average by Cap. -0.68%-0.58%+95.93%+140.54%

Financials

2026 *2027 *
Net sales 325K 440K 380K 357K 611K 42.07M 621K 4.18M 1.64M 21.07M 1.65M 1.62M 70.01M 751K 1.02M 878K 825K 1.41M 97.23M 1.43M 9.67M 3.78M 48.69M 3.82M 3.73M 162M
Net income -41.45M -56.15M -48.5M -45.58M -77.93M -5.37B -79.21M -534M -209M -2.69B -211M -206M -8.94B -66.28M -89.8M -77.56M -72.88M -125M -8.59B -127M -854M -334M -4.3B -337M -330M -14.29B
Net Debt -133M -180M -156M -146M -250M -17.24B -254M -1.71B -670M -8.63B -677M -662M -28.69B -174M -236M -204M -191M -327M -22.55B -333M -2.24B -877M -11.29B -885M -866M -37.52B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
14/08/26 USD 13.72 -1.79% 824,056
13/08/26 USD 13.97 +2.87% 2,814,361
12/08/26 USD 13.58 -7.74% 5,443,587
11/08/26 USD 14.72 -4.60% 3,289,354
10/08/26 USD 15.43 +29.12% 16,208,741
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
13.72USD
Average target price
33.00USD
Spread / Average Target
+140.52%

Quarterly revenue - Rate of surprise