Valuation: Silence Therapeutics plc

Market Cap 549M 735M 641M 605M 1.03B 70.48B 1.03B 7.24B 2.8B 35.84B 2.76B 2.7B 115B P/E 2026 *
-22.9x
P/E 2027 * -18.4x
Enterprise Value 416M 557M 485M 458M 780M 53.4B 783M 5.49B 2.12B 27.15B 2.09B 2.04B 87.36B EV / Sales 2026 *
1,291x
EV / Sales 2027 * 500x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -
1 day-3.94%
1 week-6.30%
Current month-9.83%
1 month-13.48%
3 months+76.05%
6 months+84.01%
Current year+100.66%
1 week 12.1
Extreme 12.1
13.28
1 month 12.1
Extreme 12.1
15.28
Current year 4.19
Extreme 4.19
17.58
1 year 4.19
Extreme 4.19
17.58
3 years 1.97
Extreme 1.97
27.72
5 years 1.97
Extreme 1.97
27.72
10 years 1.97
Extreme 1.97
35
Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Date Insider Type Main position Quantity % Market Cap. Importance
6/7/26 Sell 865,112 0.6105%
2/1/26 Free

Chief Financial Officer

375,000 0.2646%
2/1/26 Free

Director

90,000 0.0635%
Change 5-day change 1-year change 3-year change Capi.($)
-3.94%-6.30%+142.54%+25.39% 735M
+0.11%+2.71%+0.33%+28.59% 46.28B
-1.12%+1.78%+40.07%+27.26% 43.85B
-3.04%-6.29%+322.27%+517.36% 40.93B
-0.74%+1.25%+2.32%+67.94% 39.9B
-0.50%+0.67%+11.79%+40.51% 29.5B
-0.46%+4.22%+21.99%+124.21% 17.09B
-0.97%-10.17% - - 15.55B
-0.57%+8.12%+22.15%+38.93% 15.22B
-3.14%+31.91%-10.60% - 14.05B
Average -1.29%+2.76%+61.43%+108.77% 26.31B
Weighted average by Cap. -1.03%+1.85%+64.92%+129.90%

Financials

2026 *2027 *
Net sales 322K 431K 376K 355K 604K 41.38M 607K 4.25M 1.64M 21.04M 1.62M 1.58M 67.69M 751K 1M 875K 827K 1.41M 96.32M 1.41M 9.9M 3.82M 48.97M 3.77M 3.69M 158M
Net income -42.14M -56.36M -49.14M -46.4M -78.95M -5.41B -79.27M -556M -214M -2.75B -212M -207M -8.85B -71.01M -94.97M -82.82M -78.2M -133M -9.11B -134M -937M -361M -4.63B -357M -349M -14.91B
Net Debt -133M -178M -155M -147M -249M -17.08B -250M -1.76B -678M -8.68B -669M -654M -27.94B -174M -233M -203M -192M -326M -22.34B -327M -2.3B -886M -11.36B -874M -855M -36.54B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
Employees
88
Date Price Change Volume
18/09/26 USD 12.20 -3.94% 1,142,412
17/09/26 USD 12.70 +1.60% 690,466
16/09/26 USD 12.50 +0.32% 983,806
15/09/26 USD 12.46 -4.59% 1,383,436
14/09/26 USD 13.06 +0.31% 1,095,255
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
-
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
7
Last Close Price
12.20USD
Average target price
33.00USD
Spread / Average Target
+170.49%

Quarterly revenue - Rate of surprise

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