Valuation: Silence Therapeutics plc

Market Cap 587M 800M 685M 642M 1.11B 76.24B 1.12B 7.57B 2.95B 38.46B 3B 2.94B 127B P/E 2026 *
-19.7x
P/E 2027 * -16.3x
Enterprise Value 453M 618M 530M 496M 856M 58.94B 864M 5.86B 2.28B 29.74B 2.32B 2.27B 98.47B EV / Sales 2026 *
1,396x
EV / Sales 2027 * 550x
Free-Float
69.35%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: Silence Therapeutics plc

Manager TitleAgeSince
Chief Executive Officer 72 01/12/2025
Director of Finance/CFO 54 01/02/2022
Chief Tech/Sci/R&D Officer - 01/01/2021
Director TitleAgeSince
Director/Board Member 63 21/06/2018
Chairman 72 01/01/2004
Director/Board Member 65 05/05/2025
Change 5-day change 1-year change 3-year change Capi.($)
+1.02%+4.84%+4.80%+24.36% 51.21B
-0.09%-0.29%+471.14%+564.30% 45.35B
-0.32%+7.54%+35.72%+20.37% 42.84B
+1.18%+3.82%+19.99%+89.24% 42.29B
-2.27%-5.67%+14.55%+50.34% 32.15B
-0.96%+2.84%+32.44%+142.88% 17.31B
+0.41%+2.26% - - 16.55B
+1.12%+5.83%+8.37%+32.33% 14.84B
-0.31%+3.84%+83.91%+49.85% 14.25B
Average +0.00%+3.06%+83.86%+121.71% 30.75B
Weighted average by Cap. +0.10%+2.89%+101.20%+141.28%

Financials

2026 *2027 *
Net sales 325K 443K 379K 356K 613K 42.21M 619K 4.19M 1.63M 21.3M 1.66M 1.63M 70.53M 751K 1.02M 877K 822K 1.42M 97.56M 1.43M 9.69M 3.77M 49.22M 3.84M 3.76M 163M
Net income -41.45M -56.51M -48.43M -45.38M -78.22M -5.39B -79M -535M -208M -2.72B -212M -208M -9B -66.28M -90.37M -77.44M -72.56M -125M -8.62B -126M -856M -333M -4.35B -339M -332M -14.4B
Net Debt -133M -181M -155M -146M -251M -17.3B -254M -1.72B -669M -8.73B -681M -667M -28.91B -174M -237M -203M -191M -328M -22.62B -332M -2.25B -875M -11.41B -891M -872M -37.8B
Logo Silence Therapeutics plc
Silence Therapeutics plc is a global clinical-stage biotechnology company engaged in transforming people’s lives by silencing diseases through precision-engineered medicines created with proprietary siRNA (short interfering RNA) technology. The Company leverages its mRNAi GOLD platform to create siRNAs designed to precisely target and silence disease-associated genes in the liver. The Company focuses on areas of high unmet medical need with programs advancing cardiovascular disease, hematology and rare diseases. Divesiran (SLN124) is its wholly owned siRNA product candidate designed to inhibit TMPRSS6 expression in the liver. Zerlasiran is a siRNA molecule designed for the treatment of cardiovascular disease associated with elevated Lp(a), a lipoprotein in the blood. In addition to its wholly owned clinical pipeline, it has a third siRNA product candidate from its mRNAi GOLD platform in Phase I development in an undisclosed indication through its collaboration with AstraZeneca.
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