Valuation: Septerna, Inc.

Market Cap 1.85B 1.6B 1.51B 1.37B 2.57B 177B 2.59B 18.04B 6.94B 89.79B 6.93B 6.78B 286B P/E 2026 *
-29.3x
P/E 2027 * -17.3x
Enterprise Value 1.47B 1.27B 1.2B 1.09B 2.04B 141B 2.06B 14.33B 5.51B 71.31B 5.51B 5.38B 227B EV / Sales 2026 *
15.3x
EV / Sales 2027 * 18.6x
Free-Float
99.08%
Yield 2026 *
-
Yield 2027 * -
1 day-1.34%
1 week+4.09%
Current month+1.97%
1 month-11.99%
3 months+7.97%
6 months+54.73%
Current year+39.53%
1 week 36.6
Extreme 36.6
40.02
1 month 36.01
Extreme 36.01
45.41
Current year 22.78
Extreme 22.78
51.1
1 year 14.35
Extreme 14.35
51.1
3 years 4.17
Extreme 4.17
51.1
5 years 4.17
Extreme 4.17
51.1
10 years 4.17
Extreme 4.17
51.1
Manager TitleAgeSince
Chief Executive Officer 60 01/11/2021
Director of Finance/CFO 55 06/01/2025
President 58 01/08/2025
Director TitleAgeSince
Director/Board Member 60 01/11/2021
Chairman 50 01/11/2021
Director/Board Member 41 01/11/2021
Date Insider Type Main position Quantity % Market Cap. Importance
8/9/26 Free

Chief Technology Officer

275,000 0.5892%
1/9/26 Exercice

Executive/Senior Manager

9,999 0.0214%
12/8/26
RA Capital Management LP
SellCompany -1,493,000 3.3122%
Change 5-day change 1-year change 3-year change Capi.($)
-1.34%+4.09%+168.83% - 1.85B
+0.56%-3.38%-1.83%+8.00% 45.63B
-1.17%-2.17%+339.03%+538.63% 43.96B
+2.25%+4.58%+45.76%+28.04% 43.73B
-1.98%-1.01%+4.71%+73.69% 40.23B
-0.73%-4.72%+8.55%+37.89% 31.86B
-12.06%-13.51% - - 17.4B
+3.73%+4.55%+24.45%+120.65% 16.62B
+1.83%+3.20%+16.49%+32.73% 14.46B
+0.51%-2.40%+80.00%+31.82% 13.04B
Average -0.87%-0.87%+76.22%+108.93% 26.88B
Weighted average by Cap. -0.58%-2.03%+76.71%+129.59%

Financials

2026 *2027 *
Net sales 96.09M 83.23M 78.7M 71.25M 134M 9.22B 135M 939M 361M 4.67B 361M 353M 14.9B 73.66M 63.8M 60.33M 54.62M 103M 7.07B 103M 720M 277M 3.58B 277M 271M 11.43B
Net income -61.3M -53.1M -50.21M -45.45M -85.31M -5.88B -85.95M -599M -231M -2.98B -230M -225M -9.51B -115M -99.68M -94.26M -85.34M -160M -11.04B -161M -1.12B -433M -5.6B -432M -423M -17.85B
Net Debt -380M -329M -311M -282M -529M -36.45B -533M -3.71B -1.43B -18.48B -1.43B -1.4B -58.94B -476M -413M -390M -353M -663M -45.69B -668M -4.66B -1.79B -23.17B -1.79B -1.75B -73.88B
Logo Septerna, Inc.
Septerna, Inc. is a clinical-stage biotechnology company. The Company is developing G protein-coupled receptor (GPCR) oral small-molecule drug discovery powered by its proprietary Native Complex Platform. Its pipeline of product candidates is focused on treating patients in three therapeutic areas: endocrinology, immunology and inflammation, and metabolic diseases. Its industrial-scale Native Complex Platform is designed to target certain GPCRs for the first time, uncover novel binding pockets for validated receptors, and pursue a wide spectrum of pharmacologies, including agonists, antagonists, and allosteric modulators, to achieve desired therapeutic effects. It is advancing a deep portfolio of oral small molecule GPCR-targeted programs with novel mechanistic approaches to treat diseases across multiple therapeutic areas for patients with unmet needs. It is focused on therapeutic areas, such as neurology, women’s health, cardiovascular, and respiratory disease.
Employees
123
Date Price Change Volume
16/09/26 USD 39.21 -0.86% 95,687
14/09/26 USD 39.55 +2.70% 356,039
11/09/26 USD 38.51 +2.01% 354,801
10/09/26 USD 37.75 -0.58% 338,723
09/09/26 USD 37.97 +1.61% 475,312
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
10
Last Close Price
39.55USD
Average target price
54.22USD
Spread / Average Target
+37.10%

Quarterly revenue - Rate of surprise

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