Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 8.6B 7.48B 6.96B 6.39B 12.07B 821B 12.26B 82.06B 32.2B 409B 32.31B 31.6B 1,371B P/E 2026 *
-14.6x
P/E 2027 * -28.3x
Enterprise Value 8.21B 7.14B 6.64B 6.1B 11.51B 784B 11.69B 78.28B 30.72B 390B 30.83B 30.15B 1,308B EV / Sales 2026 *
8.9x
EV / Sales 2027 * 5.97x
Free-Float
99.09%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 8.6B
-1.40%+2.59%-1.71%+11.28% 48.53B
-2.41%-0.90%+411.96%+495.33% 39.87B
-1.16%+12.96%+28.81%+7.25% 38.68B
-1.88%-3.03%+5.69%+53.00% 35.13B
-1.74%+5.12%+14.44%+41.77% 29.79B
-0.21%-4.04%+36.40%+125.75% 16.11B
-2.85%-3.92% - - 16.08B
-0.64%+2.65%+3.40%+13.11% 13.61B
-1.19%-1.32%-1.73%-34.37% 12.62B
Average -1.22%+1.05%+62.16%+89.14% 27.82B
Weighted average by Cap. -1.50%+2.03%+79.78%+108.61%

Financials

2026 *2027 *
Net sales 922M 802M 746M 685M 1.29B 88.04B 1.31B 8.8B 3.45B 43.83B 3.46B 3.39B 147B 1.4B 1.22B 1.13B 1.04B 1.97B 134B 2B 13.37B 5.25B 66.61B 5.26B 5.15B 223B
Net income -589M -512M -477M -438M -827M -56.26B -840M -5.62B -2.21B -28.01B -2.21B -2.16B -93.93B -317M -275M -256M -235M -444M -30.23B -451M -3.02B -1.19B -15.05B -1.19B -1.16B -50.46B
Net Debt -396M -344M -320M -294M -555M -37.76B -564M -3.77B -1.48B -18.8B -1.49B -1.45B -63.03B -241M -209M -195M -179M -338M -22.97B -343M -2.3B -901M -11.44B -904M -884M -38.35B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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