Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 9.08B 7.93B 7.33B 6.78B 12.76B 872B 12.99B 87.46B 34.31B 427B 34.1B 33.34B 1,470B P/E 2026 *
-15.2x
P/E 2027 * -31.1x
Enterprise Value 8.83B 7.71B 7.13B 6.59B 12.4B 848B 12.63B 85.02B 33.36B 415B 33.15B 32.42B 1,429B EV / Sales 2026 *
9.93x
EV / Sales 2027 * 6.43x
Free-Float
99.09%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: ISIS Pharmaceuticals, Inc.

Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 9.08B
-0.17%+1.36%+3.05%+7.32% 50.35B
-0.54%-3.49%+384.40%+588.28% 39.32B
+0.57%+2.74%+32.79%-5.42% 34.69B
+2.28%+3.63%+16.00%+58.08% 34.08B
+1.68%-1.40%+4.23%+27.34% 26.63B
-0.05%-4.48% - - 16.49B
-0.97%-0.18%+69.81%+114.67% 15.31B
+0.43%+3.34%+14.96%+17.98% 13.8B
+0.23%+2.28%+16.26%-30.93% 12.87B
Average +0.47%-0.41%+67.69%+97.17% 27.06B
Weighted average by Cap. +0.45%-0.32%+81.70%+121.68%

Financials

2026 *2027 *
Net sales 889M 777M 718M 664M 1.25B 85.4B 1.27B 8.57B 3.36B 41.82B 3.34B 3.27B 144B 1.4B 1.22B 1.13B 1.04B 1.97B 134B 2B 13.47B 5.29B 65.77B 5.25B 5.14B 226B
Net income -596M -521M -481M -445M -837M -57.22B -852M -5.74B -2.25B -28.02B -2.24B -2.19B -96.48B -296M -259M -239M -221M -417M -28.47B -424M -2.86B -1.12B -13.94B -1.11B -1.09B -48B
Net Debt -252M -221M -204M -188M -355M -24.25B -361M -2.43B -954M -11.88B -948M -927M -40.89B -86.16M -75.29M -69.6M -64.31M -121M -8.28B -123M -830M -326M -4.05B -324M -316M -13.95B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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