Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 9.06B 7.83B 7.31B 6.71B 12.62B 862B 12.82B 85.82B 33.68B 432B 34B 33.26B 1,428B P/E 2026 *
-15.2x
P/E 2027 * -29.5x
Enterprise Value 8.66B 7.49B 7B 6.42B 12.07B 824B 12.26B 82.07B 32.21B 413B 32.52B 31.81B 1,366B EV / Sales 2026 *
9.41x
EV / Sales 2027 * 6.29x
Free-Float
99.09%
Yield 2026 *
-
Yield 2027 * -
Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 9.06B
+0.99%+1.78%+4.07%+16.73% 48.7B
+2.07%+7.83%+478.60%+582.25% 42.05B
+1.78%+0.83%+32.43%+8.06% 38.26B
+4.59%+9.20%+15.69%+84.03% 37.5B
+2.21%+4.89%+17.24%+51.64% 31.44B
+2.35%+4.69% - - 16.47B
-0.18%+1.20%+36.21%+124.29% 16.33B
-0.11%+2.41%+6.24%+18.87% 13.98B
-0.96%+12.84%+75.17%+27.81% 12.68B
Average +1.44%+3.06%+83.21%+114.21% 28.6B
Weighted average by Cap. +1.86%+2.31%+100.97%+137.09%

Financials

2026 *2027 *
Net sales 921M 796M 744M 682M 1.28B 87.63B 1.3B 8.73B 3.43B 43.92B 3.46B 3.38B 145B 1.4B 1.21B 1.13B 1.04B 1.95B 133B 1.98B 13.28B 5.21B 66.86B 5.26B 5.15B 221B
Net income -590M -510M -477M -437M -822M -56.15B -835M -5.59B -2.19B -28.14B -2.22B -2.17B -93.04B -319M -276M -257M -236M -444M -30.34B -451M -3.02B -1.19B -15.2B -1.2B -1.17B -50.27B
Net Debt -396M -342M -320M -293M -551M -37.65B -560M -3.75B -1.47B -18.87B -1.49B -1.45B -62.38B -241M -208M -194M -178M -335M -22.91B -341M -2.28B -895M -11.48B -904M -884M -37.95B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
Employees
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Global
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ESG MSCI
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