Valuation: ISIS Pharmaceuticals, Inc.

Market Cap 8.99B 7.86B 7.25B 6.68B 12.59B 866B 12.87B 86.64B 34.08B 424B 33.76B 33.02B 1,459B P/E 2026 *
-15x
P/E 2027 * -29.6x
Enterprise Value 8.74B 7.63B 7.04B 6.49B 12.24B 841B 12.51B 84.2B 33.12B 412B 32.81B 32.09B 1,418B EV / Sales 2026 *
9.82x
EV / Sales 2027 * 6.41x
Free-Float
99.09%
Yield 2026 *
-
Yield 2027 * -

Last Transcript: ISIS Pharmaceuticals, Inc.

Manager TitleAgeSince
Investor Relations Contact 60 01/07/2012
Chief Executive Officer 64 01/01/2020
Director of Finance/CFO 64 01/05/2000
Director TitleAgeSince
Director/Board Member 64 13/12/2005
Director/Board Member 73 01/05/2002
Director/Board Member 64 25/03/2019
Change 5-day change 1-year change 3-year change Capi.($)
+1.33%+2.73% - - 8.99B
-1.29%-3.11%-0.35%+3.09% 49.18B
+3.90%-0.39%+386.06%+593.85% 39.58B
-1.70%+4.46%+5.93%+60.25% 34.69B
-2.01%-0.76%+28.41%-8.01% 34.42B
+0.06%+0.34%+2.38%+34.38% 27.11B
+0.46%-3.49% - - 16.21B
-0.04%-0.09%+72.42%+115.55% 15.36B
+1.12%+1.91%+14.54%+19.16% 14.05B
0.00%+1.36%+18.43%-30.79% 13.02B
Average +0.18%+0.03%+65.98%+98.43% 27.07B
Weighted average by Cap. -0.00%-0.18%+79.44%+123.32%

Financials

2026 *2027 *
Net sales 889M 777M 717M 661M 1.25B 85.63B 1.27B 8.57B 3.37B 41.94B 3.34B 3.27B 144B 1.39B 1.21B 1.12B 1.03B 1.95B 134B 1.99B 13.38B 5.26B 65.49B 5.21B 5.1B 225B
Net income -598M -523M -482M -445M -838M -57.61B -857M -5.77B -2.27B -28.22B -2.25B -2.2B -97.13B -309M -270M -249M -230M -433M -29.79B -443M -2.98B -1.17B -14.59B -1.16B -1.14B -50.22B
Net Debt -252M -221M -204M -188M -354M -24.32B -362M -2.43B -957M -11.91B -948M -927M -40.99B -86.16M -75.29M -69.48M -64.04M -121M -8.3B -123M -830M -327M -4.06B -324M -316M -13.99B
Logo ISIS Pharmaceuticals, Inc.
Ionis Pharmaceuticals, Inc. develops six marketed medicines for serious diseases, including medicines for neurologic and cardiovascular diseases. Its marketed medicines consist of TRYNGOLZA, WAINUA (eplontersen), SPINRAZA (nusinersen), QALSODY (tofersen), TEGSEDI (inotersen) and WAYLIVRA (volanesorsen). TRYNGOLZA reduces triglyceride levels in adults with familial chylomicronemia syndrome (FCS). WAINUA is approved for the treatment of the polyneuropathy of hereditary transthyretin-medicated amyloidosis (ATTRv-PN) in adults. SPINRAZA is used for the treatment of pediatric and adult patients with spinal muscular atrophy. QALSODY is approved for the treatment of Amyotrophic Lateral Sclerosis in adults who have a mutation in the superoxide dismutase 1 (SOD1) gene, or SOD1-ALS. TEGSEDI is approved for the treatment of ATTRv-PN in adults. WAYLIVRA is approved as an adjunct to diet in adult patients with genetically confirmed FCS and at high risk of acute, potentially fatal pancreatitis.
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