Valuation : Denali Therapeutics Inc.

Market Cap 3.45B 2.97B 2.79B 2.55B 4.76B 328B 4.78B 33.11B 12.8B 167B 12.95B 12.67B 530B P/E 2026 *
-9.33x
P/E 2027 * -9.41x
Enterprise Value 2.74B 2.36B 2.22B 2.02B 3.78B 261B 3.8B 26.31B 10.17B 133B 10.29B 10.06B 421B EV / Sales 2026 *
54.2x
EV / Sales 2027 * 20.8x
Free-Float
90.04%
Yield 2026 *
-
Yield 2027 * -
1 day-0.46%
1 week-6.84%
Current month-10.61%
1 month-15.04%
3 months+3.06%
6 months-0.89%
Current year+28.65%
1 week 21.09
Extreme 21.09
22.48
1 month 21.09
Extreme 21.09
25.7
Current year 15.34
Extreme 15.34
27.3
1 year 12.58
Extreme 12.58
27.3
3 years 10.57
Extreme 10.57
33.33
5 years 10.57
Extreme 10.57
56.08
10 years 10.57
Extreme 10.57
93.94
Manager TitleAgeSince
Director of Finance/CFO 52 01/05/2022
Chief Executive Officer 50 01/08/2015
Chief Tech/Sci/R&D Officer 58 06/11/2025
Director TitleAgeSince
Director/Board Member 50 01/03/2015
Director/Board Member 73 01/04/2015
Director/Board Member 68 01/04/2015
Date Insider Type Main position Quantity % Market Cap. Importance
2/9/26 Sell

Director

-11,439 0.0072%
1/9/26 Sell

Founder

-2,768 0.0017%
12/8/26 Don

Founder

-32,220 0.0203%
Change 5-day change 1-year change 3-year change Capi.($)
-0.81%-6.84%+45.08%-11.24% 3.45B
-0.94%-0.71%+45.60%+103.25% 68.52B
-0.58%-5.74%+31.14%+74.90% 62.88B
-0.55%-0.21%-13.38%+377.02% 28.13B
-2.74%-6.31%+26.33%+11.24% 25.56B
-1.48%-6.29%-4.54%-18.26% 24.65B
-2.16%-5.10%+17.86%-19.56% 19.81B
-4.27%+3.07%+211.22%+362.48% 17.69B
-1.37%-4.51%-5.21%+507.43% 14.66B
-0.63%-2.20%+53.40%+162.98% 14.45B
Average -1.53%-2.03%+40.75%+155.02% 27.98B
Weighted average by Cap. -1.35%-1.91%+36.49%+135.84%

Financials

2026 *2027 *
Net sales 50.57M 43.52M 40.97M 37.33M 69.85M 4.81B 70.13M 486M 188M 2.45B 190M 186M 7.77B 130M 111M 105M 95.62M 179M 12.32B 180M 1.24B 481M 6.28B 486M 476M 19.89B
Net income -454M -390M -368M -335M -627M -43.17B -629M -4.36B -1.68B -21.99B -1.7B -1.67B -69.67B -449M -387M -364M -332M -621M -42.77B -623M -4.32B -1.67B -21.79B -1.69B -1.65B -69.02B
Net Debt -708M -610M -574M -523M -979M -67.41B -982M -6.8B -2.63B -34.34B -2.66B -2.6B -109B -749M -644M -607M -553M -1.03B -71.24B -1.04B -7.19B -2.78B -36.29B -2.81B -2.75B -115B
Logo Denali Therapeutics Inc.
Denali Therapeutics Inc. is a biopharmaceutical company establishing a new class of biotherapeutics designed to cross the blood-brain barrier using its TransportVehicle platform. It is focused on building a portfolio of therapeutic candidates by investing in its TV franchises, i.e., Enzyme TV (ETV), Oligonucleotide TV (OTV), and Antibody TV (ATV), to advance programs for rare diseases, such as lysosomal storage diseases, and common diseases, such as Alzheimer's disease and Parkinson's disease. Its most advanced TV-enabled program is tividenofusp alfa (DNL310, ETV:IDS) for the potential treatment of mucopolysaccharidosis II (Hunter syndrome). TV-enabled clinical development portfolio also includes DNL126 (ETV:SGSH) for mucopolysaccharidosis IIIA (Sanfilippo syndrome type A), DNL593 (PTV:PGRN) for frontotemporal dementia-granulin, DNL628 (OTV:MAPT) for Alzheimer’s disease, and DNL952 (ETV:GAA) for Pompe disease. It is also pursuing opportunities in other disease areas including oncology.
Employees
503
Date Price Change Volume
10/09/26 USD 21.29 -1.30% 23,786
09/09/26 USD 21.57 -2.31% 2,091,526
08/09/26 USD 22.08 -0.90% 1,653,769
04/09/26 USD 22.28 -2.28% 799,633
03/09/26 USD 22.80 -0.22% 1,727,981
Trader
Investor
-
Global
-
Quality
-
ESG MSCI
BB
Sell
Consensus
Buy
Mean consensus
BUY
Number of Analysts
20
Last Close Price
21.57USD
Average target price
36.06USD
Spread / Average Target
+67.19%

Quarterly revenue - Rate of surprise

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